Positive regulation of cell junction assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRA, PMEPA1, and MSRB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell junction assembly activity versus EDNRA in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EDNRA →	+0.990	+0.692	<.001	<.001	3	4
LSCC	PMEPA1 →	+0.632	+0.342	.007	.001	3	4
BRCA	MSRB3 →	+0.914	+0.518	.002	.001	3	4
BRCA	PARVA →	+0.442	+0.389	<.001	<.001	3	4
LSCC	EVA1A →	+0.776	+0.475	.001	.002	3	3
CCRCC	DSTN →	+0.577	+0.485	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901890 vs EDNRA — BRCA

Explore this scatter interactively →