Positive regulation of cell junction assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TJP1_S1619, LEO1_S658, and ALS2_S1464, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell junction assembly activity versus TJP1_S1619 in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TJP1_S1619 →	+0.530	+0.760	<.001	<.001	3	3
OV	LEO1_S658 →	-0.523	-0.270	<.001	.001	3	3
UCEC	ALS2_S1464 →	-1.012	-0.748	<.001	<.001	3	3
BRCA	TFIP11 →	-0.203	-0.438	<.001	<.001	3	3
OV	SPEN_T3467 →	-0.801	-0.294	.002	<.001	3	3
PDAC	PEAK1_S826 →	+0.550	+0.509	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901890 vs TJP1_S1619 — LUAD

Explore this scatter interactively →