Positive regulation of cell junction assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT6, DYNLRB1, and SMIM17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B4GALT6 grouped by Positive regulation of cell junction assembly-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	B4GALT6 →	-2.399	-1.615	.006	<.001	3	3
LUNG_NSCLC_LUSC	DYNLRB1 →	-0.658	-0.856	.004	.009	3	3
LUNG_SCLC	SMIM17 →	-0.678	-1.193	.002	<.001	3	3
BLOOD_Myeloma	BCL2L13 →	+0.968	+1.512	.007	.003	2	4
OVARY	CCNE1 →	+1.539	+0.889	.001	.004	3	3
OVARY	CRIM1 →	-1.668	-0.920	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B4GALT6 by Positive regulation of cell junction assembly activity — BONE

Explore this box plot interactively →