Negative regulation of cell junction assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, MXRA7, and MYO5C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Negative regulation of cell junction assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MDM2 →	+1.522	+1.366	<.001	<.001	3	6
LUNG_NSCLC_LUSC	MXRA7 →	-1.940	-1.228	<.001	.003	3	5
LUNG_NSCLC_LUSC	MYO5C →	+2.370	+1.065	<.001	<.001	3	5
BREAST	DBP →	+0.892	+0.911	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MTARC1 →	+3.083	+1.235	.002	.006	3	5
BLOOD_Leukemia	UNC119 →	+0.727	+1.051	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Negative regulation of cell junction assembly activity — BLOOD_Leukemia

Explore this box plot interactively →