Negative regulation of cell junction assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, DUSP10, and ABLIM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell junction assembly activity versus TGFBI in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TGFBI →	+2.697	+0.845	.003	.005	3	7
LUNG_NSCLC_LUAD	DUSP10 →	+1.375	+0.554	<.001	.003	3	6
SKIN	ABLIM3 →	+1.527	+0.288	.004	.009	3	6
STOMACH	SH3BGRL3 →	+0.900	+0.860	.006	.003	3	5
OVARY	XPOT →	-0.804	-1.145	.006	<.001	3	5
KIDNEY	CENPV →	-2.276	-0.167	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901889 vs TGFBI — LUNG_NSCLC_LUAD

Explore this scatter interactively →