Regulation of protein depolymerization

Across TCGA cell cohorts, RNA activity of the Regulation of protein depolymerization pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WSB1, SENP3-EIF4A1, and ZBTB24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WSB1 grouped by Regulation of protein depolymerization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	WSB1 →	-0.310	-0.071	.001	.002	3	5
BREAST	SENP3-EIF4A1 →	-0.181	-0.069	<.001	<.001	3	5
KIDNEY	ZBTB24 →	-0.176	-0.071	.001	<.001	3	4
LIVER	IRX4 →	-0.341	-0.097	.003	.003	3	4
PANCREAS	ZNF219 →	-0.181	-0.085	.008	.003	2	5
LUNG_NSCLC_LUSC	ZKSCAN5 →	+0.228	+0.064	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WSB1 by Regulation of protein depolymerization activity — LIVER

Explore this box plot interactively →