Positive regulation of post-translational protein modification

Across TCGA cell cohorts, RNA activity of the Positive regulation of post-translational protein modification pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RABL3, ZFP1, and PCNP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-translational protein modification activity versus RABL3 in LARGE_INTESTINE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RABL3 →	+0.559	+0.190	<.001	<.001	3	5
LARGE_INTESTINE	ZFP1 →	+1.184	+0.176	<.001	.001	3	5
PANCREAS	PCNP →	+0.870	+0.351	<.001	<.001	3	5
LUNG_SCLC	CNBP →	+0.605	+0.293	<.001	<.001	3	5
BONE	CIRBP →	+1.268	+0.415	.001	.002	3	5
CNS	ARRB1 →	+1.207	+0.199	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901875 vs RABL3 — LARGE_INTESTINE

Explore this scatter interactively →