Positive regulation of muscle tissue development

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK2, PLOD2, and FOSL2_S120, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle tissue development activity versus HK2 in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HK2 →	-0.569	-0.055	<.001	<.001	3	8
CCRCC	PLOD2 →	-1.287	-0.098	<.001	<.001	3	8
CCRCC	FOSL2_S120 →	-0.535	-0.077	.001	.003	3	8
CCRCC	MAPK6_S189 →	-0.613	-0.090	.001	<.001	3	8
LUAD	KIF23_S867 →	-0.811	-0.048	.002	.008	2	8
LUAD	RACGAP1 →	-0.631	-0.061	.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901863 vs HK2 — PDAC

Explore this scatter interactively →