Positive regulation of muscle tissue development

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKAP2L, TCTEX1D1, and FAM83D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle tissue development activity versus CKAP2L in LUAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CKAP2L →	-0.654	-0.206	<.001	<.001	3	5
GBM	TCTEX1D1 →	+0.708	+0.122	.006	.008	3	4
OV	FAM83D →	-1.285	-0.624	<.001	.005	3	4
LUAD	ANLN →	-0.868	-0.173	<.001	<.001	3	4
LUAD	DLGAP5 →	-0.901	-0.163	<.001	<.001	3	4
LUAD	SKA1 →	-0.980	-0.263	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901863 vs CKAP2L — LUAD

Explore this scatter interactively →