Positive regulation of muscle tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD9, FOXA1, and LRRC8C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD9 grouped by Positive regulation of muscle tissue development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MFSD9 →	+1.011	+0.213	.009	<.001	3	5
URINARY_TRACT	FOXA1 →	+3.601	+0.292	<.001	<.001	3	5
LUNG_NSCLC_LUSC	LRRC8C →	-1.306	-0.217	.001	.003	3	5
BONE	CXorf56 →	-0.718	-0.270	.003	.006	3	5
LIVER	EPHX2 →	+3.156	+0.337	.009	.003	3	4
LIVER	GCH1 →	+1.769	+0.230	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD9 by Positive regulation of muscle tissue development activity — LIVER

Explore this box plot interactively →