Positive regulation of muscle tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC20, WIPF2, and CPSF7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle tissue development activity versus ZDHHC20 in LIVER (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZDHHC20 →	+1.014	+0.326	.004	.001	3	4
OESOPHAGUS	WIPF2 →	+0.762	+0.211	<.001	.002	3	4
SKIN	CPSF7 →	+0.542	+0.163	.001	.001	3	4
BREAST	TCIRG1 →	+1.403	+0.177	.001	.002	2	5
BLOOD_Myeloma	STARD3 →	+0.521	+0.322	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	MEIS3 →	-1.406	-0.289	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901863 vs ZDHHC20 — LIVER

Explore this scatter interactively →