Regulation of muscle tissue development

Across TCGA cell cohorts, RNA activity of the Regulation of muscle tissue development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INS, CTNNB1, and DHH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INS grouped by Regulation of muscle tissue development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	INS →	-0.179	-0.642	<.001	.006	3	6
LARGE_INTESTINE	CTNNB1 →	-0.914	-0.274	.002	.007	3	6
SKIN	DHH →	-0.235	-1.259	.002	<.001	3	5
CNS	NUDT8 →	-0.327	-1.147	<.001	<.001	3	5
CNS	PEX1 →	-0.223	-0.662	.009	.004	3	5
LUNG_NSCLC_LUAD	RNF34 →	-0.191	-0.765	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INS by Regulation of muscle tissue development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →