Regulation of muscle tissue development

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of muscle tissue development pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 46 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Regulation of muscle tissue development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

LGG, HNSC, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.717	0.894	<.001	54	view →
HNSC	DFS	Tertile	III,IV	0.433	0.229	.004	54	view →
OV	OS	Median	IV	0.242	0.462	.004	30	view →
UCS	DFS	Quartile	II,III,IV	0.825	0.339	.014	26	view →
ACC	OS	Quartile	All	0.236	0.685	.005	26	view →
THCA	OS	Median	II,III,IV	0.580	1.000	.013	25	view →
ESCA	OS	Tertile	IV	0.247	0.922	.024	24	view →
BRCA	OS	Tertile	III,IV	0.915	0.763	.001	20	view →
LAML	DFS	Quartile	All	0.438	0.847	.002	14	view →
KIRP	DFS	Quartile	IV	0.439	0.819	.010	12	view →
UVM	OS	Median	All	0.783	1.000	.018	12	view →
KIRC	DFS	Tertile	All	0.910	0.846	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:1901861–LGG (OS)

Open the LGG breakdown →