Regulation of muscle tissue development

Across TCGA cell cohorts, RNA activity of the Regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF101, BAG1, and MARCHF9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle tissue development activity versus ZNF101 in BLOOD_Lymphoma (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF101 →	+0.881	+0.266	.001	<.001	3	4
LUNG_SCLC	BAG1 →	+0.772	+0.224	.009	.001	3	4
LUNG_SCLC	MARCHF9 →	+1.260	+0.262	<.001	<.001	3	4
LUNG_SCLC	BIK →	+1.881	+0.208	.001	.004	2	4
LUNG_NSCLC_LUAD	ESRP1 →	+2.248	+0.665	.004	.004	3	3
LUNG_NSCLC_LUAD	SYTL1 →	+1.442	+0.463	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901861 vs ZNF101 — BLOOD_Lymphoma

Explore this scatter interactively →