Regulation of mitochondrial DNA metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCB1, TLR7, and EVI2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial DNA metabolic process activity versus ABCB1 in UCEC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABCB1 →	-0.676	-0.143	<.001	.002	3	4
OV	TLR7 →	-0.676	-0.185	.006	.004	3	4
COAD	EVI2A →	-0.661	-0.181	.001	.005	3	4
OV	MMRN1 →	-0.960	-0.252	.001	.001	3	3
UCEC	TMEM200A →	-0.810	-0.182	.002	.001	3	3
UCEC	TMEM119 →	-0.717	-0.202	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901858 vs ABCB1 — UCEC

Explore this scatter interactively →