Positive regulation of cellular respiration

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUPR1, PINK1, and HSPB7, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular respiration activity versus NUPR1 in ACC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	NUPR1 →	+2.123	+0.076	<.001	<.001	3	28
PCPG	PINK1 →	+1.068	+0.038	<.001	<.001	2	18
STAD	HSPB7 →	+1.734	+0.040	<.001	<.001	3	16
LAML	IFNG →	-0.783	-0.067	<.001	<.001	3	16
TGCT	LMNB1 →	-1.012	-0.045	<.001	<.001	3	16
TGCT	TMPO →	-0.623	-0.043	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901857 vs NUPR1 — ACC

Explore this scatter interactively →