Regulation of cell communication by electrical coupling involved in cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF2BPL, TNKS1BP1, and CAMK2D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell communication by electrical coupling involved in cardiac conduction activity versus IRF2BPL in LUNG_SCLC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IRF2BPL →	+1.273	+0.306	<.001	.001	2	6
LUNG_NSCLC_LUAD	TNKS1BP1 →	+0.763	+0.225	<.001	.002	3	5
SKIN	CAMK2D →	+1.295	+0.304	<.001	<.001	3	4
OESOPHAGUS	RNF135 →	+0.805	+0.274	.002	<.001	3	4
SKIN	TCAF2 →	+1.456	+0.230	.002	.009	3	4
SKIN	CGRRF1 →	+0.533	+0.263	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901844 vs IRF2BPL — LUNG_SCLC

Explore this scatter interactively →