Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC137, ATAD3B, and SRRT, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I activity versus CCDC137 in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCDC137 →	+1.078	+0.112	<.001	<.001	3	19
SOFT_TISSUE	ATAD3B →	+1.554	+0.123	<.001	<.001	3	18
SOFT_TISSUE	SRRT →	+1.246	+0.114	<.001	<.001	3	18
BONE	GPR75 →	+0.928	+0.174	<.001	<.001	3	18
SOFT_TISSUE	SIRT7 →	+1.203	+0.146	<.001	<.001	3	18
BONE	HAUS5 →	+1.051	+0.180	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901838 vs CCDC137 — SKIN

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