Negative regulation of proteasomal protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of proteasomal protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3D, MAP2_S1155, and NHSL2_S195, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of proteasomal protein catabolic process activity versus EIF3D in LUAD (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EIF3D →	-0.128	-0.035	.003	<.001	3	5
PDAC	MAP2_S1155 →	+1.050	+0.027	<.001	.009	2	5
PDAC	NHSL2_S195 →	+0.328	+0.018	.002	.009	3	4
CCRCC	PTPN1 →	-0.438	-0.038	<.001	<.001	3	4
LSCC	SRCIN1_S165 →	+1.207	+0.044	<.001	<.001	3	4
LSCC	ZFHX3_S2801 →	+0.328	+0.028	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901799 vs EIF3D — LUAD

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