Negative regulation of proteasomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELMO3, RTKN, and TMEM265, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELMO3 grouped by Negative regulation of proteasomal protein catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ELMO3 →	+1.929	+0.241	<.001	<.001	3	4
BLOOD_Lymphoma	RTKN →	+2.983	+0.391	.001	.003	3	4
LUNG_SCLC	TMEM265 →	+2.332	+0.325	.002	<.001	3	4
BREAST	FBXL16 →	+1.383	+0.211	.002	.001	3	4
BREAST	ARHGAP8 →	+2.026	+0.240	.002	<.001	3	4
BLOOD_Myeloma	TIAF1 →	-0.533	-0.238	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELMO3 by Negative regulation of proteasomal protein catabolic process activity — BREAST

Explore this box plot interactively →