Negative regulation of proteasomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM3, HSPE1, and CDT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of proteasomal protein catabolic process activity versus NPM3 in STOMACH (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NPM3 →	+1.243	+0.258	.003	.004	3	8
PANCREAS	HSPE1 →	+0.992	+0.327	<.001	<.001	3	7
STOMACH	CDT1 →	+1.261	+0.218	.003	.005	3	7
STOMACH	SCLY →	+1.431	+0.243	<.001	.009	3	7
STOMACH	NOB1 →	+0.839	+0.206	.008	.002	2	7
PANCREAS	HSPD1 →	+1.001	+0.531	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901799 vs NPM3 — STOMACH

Explore this scatter interactively →