Regulation of signal transduction by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Regulation of signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF3, PLLP, and RTN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of signal transduction by p53 class mediator activity versus RAPGEF3 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAPGEF3 →	-0.644	-0.202	<.001	<.001	3	6
GBM	PLLP →	-1.010	-0.185	<.001	<.001	3	5
BRCA	RTN4 →	-0.560	-0.169	<.001	.002	3	5
BRCA	TRAK2 →	-1.026	-0.256	<.001	<.001	3	5
GBM	KIAA0513 →	-0.715	-0.185	<.001	<.001	3	5
BRCA	SMIM14 →	-0.772	-0.148	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901796 vs RAPGEF3 — BRCA

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