Regulation of signal transduction by p53 class mediator

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of signal transduction by p53 class mediator pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 106 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Regulation of signal transduction by p53 class mediator pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, MESO, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.499	0.722	<.001	168	view →
MESO	OS	Quartile	All	0.199	0.540	<.001	72	view →
UVM	DFS	Quartile	II,III,IV	0.274	0.803	.001	67	view →
KIRP	DFS	Median	All	0.766	0.916	<.001	64	view →
LGG	DFS	Median	All	0.603	0.841	<.001	54	view →
THCA	DFS	Tertile	II,III,IV	0.552	0.834	<.001	52	view →
LIHC	OS	Tertile	II,III,IV	0.511	0.792	.001	48	view →
HNSC	DFS	Tertile	III,IV	0.467	0.300	.003	45	view →
UCS	DFS	Tertile	II,III,IV	0.504	0.138	.005	42	view →
ACC	OS	Median	II,III,IV	0.642	0.972	.001	33	view →
COAD	DFS	Tertile	IV	0.228	0.550	.010	23	view →
LUSC	DFS	Quartile	III,IV	0.260	0.859	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:1901796–KIRC (DFS)

Open the KIRC breakdown →