Regulation of signal transduction by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Regulation of signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAK2, PHLDA1, and RIN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of signal transduction by p53 class mediator activity versus IRAK2 in KIDNEY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IRAK2 →	+1.660	+0.143	.003	.001	3	7
BREAST	PHLDA1 →	+1.492	+0.120	.008	.002	3	5
LUNG_SCLC	RIN1 →	+1.753	+0.116	.004	.002	3	5
OVARY	NRG1 →	+2.202	+0.166	.009	.001	3	5
BREAST	TSPAN13 →	-1.770	-0.141	<.001	<.001	3	5
LUNG_SCLC	IMMP1L →	-0.943	-0.100	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901796 vs IRAK2 — KIDNEY

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