Positive regulation of myoblast fusion

Across TCGA patient cohorts, RNA activity of the Positive regulation of myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK10, SIT1, and GPR174, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myoblast fusion activity versus DOCK10 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK10 →	+0.648	+0.231	<.001	<.001	3	6
CCRCC	SIT1 →	+0.839	+0.170	<.001	<.001	3	6
HNSC	GPR174 →	+1.128	+0.269	<.001	<.001	3	6
HNSC	CCDC141 →	+0.804	+0.269	<.001	<.001	3	6
HNSC	THEMIS →	+0.932	+0.240	<.001	.002	3	6
HNSC	DTHD1 →	+0.942	+0.226	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901741 vs DOCK10 — LSCC

Explore this scatter interactively →