Negative regulation of cell proliferation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell proliferation involved in kidney development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCD1, LLGL1, and SEPTIN7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell proliferation involved in kidney development activity versus PLCD1 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLCD1 →	+0.443	+0.116	.001	<.001	3	6
GBM	LLGL1 →	+0.365	+0.102	.002	.005	3	6
GBM	SEPTIN7 →	+0.291	+0.143	<.001	<.001	3	5
BRCA	SORBS3 →	+0.386	+0.075	<.001	<.001	3	5
GBM	STXBP2 →	-0.476	-0.101	.001	<.001	3	5
UCEC	TJP1 →	+0.335	+0.109	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901723 vs PLCD1 — UCEC

Explore this scatter interactively →