Negative regulation of cell proliferation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell proliferation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSL24D1P1, CASC4P1, and C4orf19, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell proliferation involved in kidney development activity versus RSL24D1P1 in COAD (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RSL24D1P1 →	+0.776	+0.374	<.001	<.001	3	3
COAD	CASC4P1 →	+0.380	+0.314	<.001	.006	3	3
BRCA	C4orf19 →	+0.855	+0.938	.006	<.001	3	3
BRCA	HTR7P1 →	+0.661	+0.561	.006	.008	3	3
OV	H2AC10P →	-0.747	-0.938	<.001	<.001	3	3
OV	IZUMO4 →	+0.737	+0.716	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901723 vs RSL24D1P1 — COAD

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