Negative regulation of cell proliferation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell proliferation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDIA5, AKAP9, and SWSAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDIA5 grouped by Negative regulation of cell proliferation involved in kidney development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDIA5 →	-1.244	-1.115	.003	.007	3	5
BREAST	AKAP9 →	-0.975	-0.832	<.001	.003	3	4
LUNG_NSCLC_LUAD	SWSAP1 →	-0.444	-0.931	<.001	<.001	3	4
LARGE_INTESTINE	GRIN3A →	+0.087	+0.897	.002	.002	3	4
STOMACH	LARS1 →	+0.767	+1.164	<.001	.004	3	4
BLOOD_Leukemia	PICK1 →	-1.278	-1.232	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDIA5 by Negative regulation of cell proliferation involved in kidney development activity — BLOOD_Leukemia

Explore this box plot interactively →