Nucleotide transmembrane transport

Across TCGA cell cohorts, RNA activity of the Nucleotide transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A24, SERTAD3, and SNX6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide transmembrane transport activity versus SLC25A24 in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC25A24 →	+2.683	+0.336	.008	.001	2	9
KIDNEY	SERTAD3 →	+0.572	+0.183	.001	.004	3	5
LIVER	SNX6 →	+0.967	+0.338	.003	.006	3	5
OVARY	RIC8B →	+0.689	+0.136	.006	.007	3	5
OESOPHAGUS	STXBP3 →	+1.017	+0.272	<.001	.001	3	5
PANCREAS	CLMP →	+2.398	+0.106	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901679 vs SLC25A24 — LIVER

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