Iron coordination entity transport

Across TCGA cell cohorts, RNA activity of the Iron coordination entity transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGRMC2, SGMS2, and POLD4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron coordination entity transport activity versus PGRMC2 in OESOPHAGUS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PGRMC2 →	+1.159	+0.229	.003	.003	3	7
OESOPHAGUS	SGMS2 →	+0.750	+0.161	.004	.003	2	7
BONE	POLD4 →	+1.458	+0.270	.003	<.001	3	6
OVARY	LRRFIP2 →	+0.843	+0.240	<.001	.001	2	6
PANCREAS	RUVBL1 →	-0.900	-0.359	<.001	.001	3	4
BLOOD_Leukemia	EAF2 →	-1.472	-0.101	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901678 vs PGRMC2 — OESOPHAGUS

Explore this scatter interactively →