Glycosyl compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycosyl compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXADR, INAVA, and TMEM45A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CXADR grouped by Glycosyl compound biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CXADR →	-3.557	-1.594	.007	.007	3	3
URINARY_TRACT	INAVA →	-2.597	-1.623	.007	.006	3	3
LUNG_SCLC	TMEM45A →	+2.653	+1.104	.002	.001	3	3
LUNG_NSCLC_LUSC	LMO1 →	+0.333	+1.131	.006	.004	3	3
LUNG_NSCLC_LUSC	VMP1 →	+1.328	+1.344	.002	.009	3	3
BLOOD_Lymphoma	UQCRB →	+0.867	+1.698	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CXADR by Glycosyl compound biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →