Glycosyl compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycosyl compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMACHC, MRPS27, and WDR43, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosyl compound biosynthetic process activity versus MMACHC in LIVER (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MMACHC →	+1.362	+1.454	<.001	.001	3	6
LIVER	MRPS27 →	+0.775	+1.261	.004	.004	3	5
LIVER	WDR43 →	+1.052	+1.678	.005	<.001	3	5
LIVER	EEF2 →	+0.787	+1.183	.005	.001	3	5
LIVER	DDN →	+0.850	+1.261	.002	.003	3	5
PANCREAS	WDR75 →	+1.030	+1.270	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901659 vs MMACHC — LIVER

Explore this scatter interactively →