Cellular response to ketone

Across TCGA cell cohorts, RNA activity of the Cellular response to ketone pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KREMEN2, MED28, and DIDO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KREMEN2 grouped by Cellular response to ketone-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KREMEN2 →	+2.143	+0.270	.003	<.001	3	4
STOMACH	MED28 →	-0.535	-0.372	.001	.006	3	4
LUNG_SCLC	DIDO1 →	-0.719	-0.181	.002	.004	3	3
LUNG_SCLC	PMPCB →	+0.491	+0.184	.009	.002	3	3
LUNG_SCLC	RINT1 →	+0.491	+0.221	.002	<.001	3	3
LUNG_SCLC	WDR6 →	-0.667	-0.230	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KREMEN2 by Cellular response to ketone activity — LUNG_SCLC

Explore this box plot interactively →