Regulation of synaptic vesicle membrane organization

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle membrane organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNED1, HMG20B, and METAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNED1 grouped by Regulation of synaptic vesicle membrane organization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SNED1 →	+0.168	+0.280	<.001	<.001	3	3
LIVER	HMG20B →	+0.194	+1.433	<.001	<.001	3	3
LUNG_NSCLC_LUSC	METAP1 →	-0.314	-0.101	.002	.002	3	3
OVARY	NISCH →	-0.568	-1.743	.007	<.001	3	3
LIVER	CERT1 →	+0.357	+1.693	<.001	<.001	3	2
BLOOD_Leukemia	NXPE3 →	-0.366	-1.921	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNED1 by Regulation of synaptic vesicle membrane organization activity — LUNG_SCLC

Explore this box plot interactively →