Regulation of synaptic vesicle membrane organization

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle membrane organization pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A10, NSMCE4A, and SET, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC30A10 grouped by Regulation of synaptic vesicle membrane organization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC30A10 →	+0.205	+0.522	.009	<.001	3	3
LUNG_SCLC	NSMCE4A →	+0.280	+1.577	.006	<.001	3	2
LARGE_INTESTINE	SET →	-0.277	-1.832	.006	<.001	3	2
LARGE_INTESTINE	BANK1 →	+0.145	+1.832	.004	<.001	3	2
SKIN	ENDOV →	+0.423	+0.267	.003	.005	3	2
LUNG_SCLC	SIGLEC1 →	-0.188	-1.594	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC30A10 by Regulation of synaptic vesicle membrane organization activity — BONE

Explore this box plot interactively →