Alpha-amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Alpha-amino acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMUT, AIFM1, and PRELP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-amino acid catabolic process activity versus MMUT in PDAC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MMUT →	+0.355	+0.031	<.001	<.001	3	7
OV	AIFM1 →	+0.674	+0.036	<.001	<.001	3	6
OV	PRELP →	-0.772	-0.023	.004	.006	3	6
OV	RBM47 →	+0.421	+0.037	.002	<.001	3	6
LSCC	LMNB2 →	-0.190	-0.038	<.001	<.001	3	6
CCRCC	THBS3 →	-0.470	-0.039	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901606 vs MMUT — PDAC

Explore this scatter interactively →