Alpha-amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Alpha-amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALNT1, PLK3, and SDF2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B4GALNT1 grouped by Alpha-amino acid catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	B4GALNT1 →	+1.845	+0.772	.001	.003	3	3
SKIN	PLK3 →	-0.963	-0.930	<.001	<.001	3	3
SOFT_TISSUE	SDF2 →	+0.487	+0.272	.002	.004	3	3
SOFT_TISSUE	STARD5 →	+0.804	+0.317	.004	<.001	3	3
OVARY	GIPC1 →	-0.672	-0.773	.004	.004	3	3
KIDNEY	HERC4 →	-0.607	-1.054	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B4GALNT1 by Alpha-amino acid catabolic process activity — SKIN

Explore this box plot interactively →