Fatty acid derivative biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fatty acid derivative biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPFIBP1, ATP5F1A, and BDH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative biosynthetic process activity versus PPFIBP1 in PDAC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPFIBP1 →	-0.140	-0.027	.003	.002	3	7
GBM	ATP5F1A →	+0.231	+0.044	.007	.001	3	5
PDAC	BDH1 →	+0.501	+0.034	<.001	<.001	3	5
LUAD	LDHD →	+0.452	+0.034	<.001	<.001	3	5
GBM	MAP4K5 →	-0.168	-0.027	.005	.005	3	5
GBM	ARHGAP26 →	+0.297	+0.030	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901570 vs PPFIBP1 — PDAC

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