Fatty acid derivative catabolic process

Across TCGA patient cohorts, RNA activity of the Fatty acid derivative catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIHCG, TMEM40, and ABCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative catabolic process activity versus GIHCG in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GIHCG →	-0.590	-0.195	<.001	<.001	3	5
BRCA	TMEM40 →	+0.848	+0.143	.004	.004	3	4
BRCA	ABCD1 →	+0.858	+0.216	<.001	<.001	3	4
LSCC	RPP30 →	-0.324	-0.127	.002	<.001	3	4
GBM	VRK1 →	-0.424	-0.073	<.001	.009	3	4
GBM	MIR5192 →	+0.576	+0.103	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901569 vs GIHCG — BRCA

Explore this scatter interactively →