Fatty acid derivative catabolic process

Across TCGA cell cohorts, RNA activity of the Fatty acid derivative catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP7, BDH1, and YRDC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative catabolic process activity versus FKBP7 in SKIN (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FKBP7 →	+1.389	+0.264	.002	<.001	3	4
URINARY_TRACT	BDH1 →	+1.638	+0.291	.004	.001	3	4
LUNG_SCLC	YRDC →	+0.811	+0.212	.009	.003	3	4
BLOOD_Leukemia	HM13 →	-0.304	-0.234	.006	.007	3	4
LUNG_SCLC	COA6 →	-0.500	-0.213	.001	<.001	3	4
LUNG_SCLC	RASA4B →	+0.936	+0.227	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901569 vs FKBP7 — SKIN

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