Regulation of endothelial cell development

Across TCGA patient cohorts, RNA activity of the Regulation of endothelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDIL3, MYL9, and ACTA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial cell development activity versus EDIL3 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EDIL3 →	+1.191	+0.264	.001	<.001	3	8
CCRCC	MYL9 →	+0.834	+0.333	<.001	<.001	3	8
BRCA	ACTA2 →	+1.378	+0.387	<.001	<.001	3	7
BRCA	CALD1 →	+0.998	+0.305	<.001	<.001	3	7
BRCA	TPM1 →	+0.612	+0.252	.001	<.001	3	7
UCEC	RBMS3 →	+0.721	+0.221	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901550 vs EDIL3 — BRCA

Explore this scatter interactively →