Regulation of endothelial cell development

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG6, MAP7, and JUP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial cell development activity versus PLEKHG6 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PLEKHG6 →	+1.778	+0.224	.004	.003	3	7
OESOPHAGUS	MAP7 →	+2.351	+0.329	<.001	<.001	3	6
BLOOD_Leukemia	JUP →	+2.557	+0.690	<.001	.007	3	6
BREAST	CTNND1 →	+0.797	+0.198	<.001	<.001	3	6
URINARY_TRACT	TNFAIP2 →	+3.730	+0.284	.001	.002	3	6
OVARY	LINC02693 →	-1.482	-0.291	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901550 vs PLEKHG6 — BREAST

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