Regulation of hematopoietic progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LARP1, OLFML3, and RPL32, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic progenitor cell differentiation activity versus LARP1 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LARP1 →	-0.161	-0.027	<.001	.002	3	7
UCEC	OLFML3 →	+0.632	+0.055	<.001	<.001	3	7
GBM	RPL32 →	-0.347	-0.037	<.001	.009	3	7
BRCA	SERPING1 →	+0.662	+0.042	<.001	<.001	3	7
UCEC	STXBP1 →	+0.420	+0.053	.009	.008	3	6
LSCC	FGD5 →	+0.254	+0.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901532 vs LARP1 — LSCC

Explore this scatter interactively →