Regulation of hematopoietic progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTND5P1, HMOX2, and PPP2R2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic progenitor cell differentiation activity versus MTND5P1 in PDAC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MTND5P1 →	-0.220	-0.319	<.001	<.001	3	5
PDAC	HMOX2 →	-0.286	-0.220	<.001	.003	3	4
GBM	PPP2R2C →	-0.984	-0.869	<.001	<.001	3	4
GBM	TNIK →	-0.414	-0.590	.001	.003	3	4
GBM	EPHA10 →	-0.578	-0.854	<.001	.005	2	5
OV	PCAT19 →	+0.709	+0.765	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901532 vs MTND5P1 — PDAC

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