Positive regulation of mitophagy

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitophagy pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC25A4, CTHRC1, and PPP1R18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitophagy activity versus SLC25A4 in LUAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC25A4 →	+0.589	+0.086	<.001	<.001	3	7
LUAD	CTHRC1 →	-0.918	-0.091	<.001	<.001	3	6
GBM	PPP1R18 →	-0.488	-0.120	<.001	<.001	3	6
GBM	CHDH →	+0.711	+0.110	<.001	<.001	3	6
GBM	COLGALT1 →	-0.682	-0.099	<.001	<.001	3	6
GBM	PPIB →	-0.414	-0.106	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901526 vs SLC25A4 — LUAD

Explore this scatter interactively →