Positive regulation of mitophagy

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of mitophagy pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher Positive regulation of mitophagy pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and HNSC, show the opposite pattern, with higher activity associated with better survival.

OV, KIRP, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	All	0.251	0.394	<.001	102	view →
KIRP	DFS	Median	All	0.963	0.862	<.001	81	view →
SCLC	DFS	Median	II,III,IV	0.273	0.651	<.001	60	view →
HNSC	DFS	Median	II,III,IV	0.737	0.632	.003	57	view →
MESO	OS	Median	All	0.688	0.433	<.001	55	view →
STAD	DFS	Median	All	0.547	0.285	.004	40	view →
THCA	DFS	Tertile	All	0.965	0.757	.005	40	view →
UVM	DFS	Median	All	0.350	0.724	.003	39	view →
SKCM	OS	Median	IV	0.205	0.780	.001	38	view →
LIHC	OS	Tertile	All	0.819	0.617	.003	34	view →
KIRC	DFS	Median	All	0.718	0.560	.001	30	view →
LUAD	OS	Median	All	0.441	0.261	.001	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:1901526–OV (OS)

Open the OV breakdown →