Positive regulation of mitophagy

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL17P51, RGS6, and FBXO44, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitophagy activity versus RPL17P51 in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL17P51 →	-0.142	-0.603	.003	.006	3	4
LSCC	RGS6 →	-0.901	-0.712	.003	.005	3	3
LUAD	FBXO44 →	+0.461	+0.371	<.001	.007	3	3
LUAD	RNF138 →	-0.291	-0.371	.002	.002	3	3
LUAD	SMAD2 →	-0.403	-0.500	<.001	.002	3	3
LUAD	BOLA3-AS1 →	-0.436	-0.654	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901526 vs RPL17P51 — BRCA

Explore this scatter interactively →