Positive regulation of mitophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC4, TJP3, and NMT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLIC4 grouped by Positive regulation of mitophagy-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CLIC4 →	-1.584	-0.411	.001	.001	3	4
BREAST	TJP3 →	+2.162	+0.288	.003	.005	3	4
KIDNEY	NMT2 →	-0.857	-0.388	.008	.003	3	4
KIDNEY	GPR156 →	-0.371	-0.280	.009	.008	3	4
BREAST	GNG12 →	-1.899	-0.269	<.001	<.001	3	4
URINARY_TRACT	SESN1 →	+1.865	+0.617	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLIC4 by Positive regulation of mitophagy activity — KIDNEY

Explore this box plot interactively →