Positive regulation of mitophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBI3, VANGL2, and TLE4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitophagy activity versus EBI3 in STOMACH (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EBI3 →	-1.694	-0.219	<.001	<.001	3	5
OVARY	VANGL2 →	-2.293	-0.248	<.001	.001	3	5
BREAST	TLE4 →	-2.300	-0.198	<.001	.001	3	5
BREAST	MYB →	+1.245	+0.166	.003	.001	3	5
BONE	KLF16 →	+0.663	+0.231	.003	.003	3	5
BLOOD_Leukemia	CAMKMT →	+0.589	+0.236	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901526 vs EBI3 — STOMACH

Explore this scatter interactively →