Icosanoid catabolic process

Across TCGA patient cohorts, RNA activity of the Icosanoid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPGD, PAK1, and SMC4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid catabolic process activity versus HPGD in UCEC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HPGD →	+1.260	+0.127	<.001	<.001	3	6
LUAD	PAK1 →	+0.229	+0.097	.001	<.001	3	6
LUAD	SMC4 →	-0.592	-0.103	<.001	<.001	3	5
LUAD	SMC2 →	-0.488	-0.092	<.001	<.001	3	5
UCEC	ANLN →	-0.641	-0.174	<.001	<.001	3	5
LUAD	HKDC1 →	+0.513	+0.054	.007	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901523 vs HPGD — UCEC

Explore this scatter interactively →